Optogenetic manipulation of neural and non-neural functions
نویسندگان
چکیده
منابع مشابه
Optogenetic manipulation of neural circuits in awake marmosets.
Optogenetics has revolutionized the study of functional neuronal circuitry (Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Nat Neurosci 8: 1263-1268, 2005; Deisseroth K. Nat Methods 8: 26-29, 2011). Although these techniques have been most successfully implemented in rodent models, they have the potential to be similarly impactful in studies of nonhuman primate brains. Common marmosets (...
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Optogenetic manipulation of neural activity in C. elegans: from synapse to circuits and behaviour.
The emerging field of optogenetics allows for optical activation or inhibition of excitable cells. In 2005, optogenetic proteins were expressed in the nematode Caenorhabditis elegans for the first time. Since then, C. elegans has served as a powerful platform upon which to conduct optogenetic investigations of synaptic function, circuit dynamics and the neuronal basis of behaviour. The C. elega...
متن کاملOptogenetic feedback control of neural activity
Optogenetic techniques enable precise excitation and inhibition of firing in specified neuronal populations and artifact-free recording of firing activity. Several studies have suggested that optical stimulation provides the precision and dynamic range requisite for closed-loop neuronal control, but no approach yet permits feedback control of neuronal firing. Here we present the 'optoclamp', a ...
متن کاملOptogenetic investigation of neural circuits in vivo.
The recent development of light-activated optogenetic probes allows for the identification and manipulation of specific neural populations and their connections in awake animals with unprecedented spatial and temporal precision. This review describes the use of optogenetic tools to investigate neurons and neural circuits in vivo. We describe the current panel of optogenetic probes, methods of t...
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ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2013
ISSN: 0012-1592
DOI: 10.1111/dgd.12053